BIOL210

Genomics: Modern Genetics, Bioinformatics, and the Human Genome Project

Fall, 2008 L. F. Appel

Date Session Topic (REVISED December sessions) Hartwell, et al. Notes, Assignments
Sept. 3 1 Introduction 
Genetics, the Study of Biological Information
Ch. 1 The Salvation of Doug;
The Demise of Bill;
8 2 Transmission Genetics
Mendelian Genetics I: Mono- and Dihybrid Crosses
Ch. 2 MendelWeb
10 3 Mendelian Genetics II: Variations and Complications Ch. 3 e-prob set Ch 2 due by noon
15 4 Lab: Corn Epistatis p. 128 -
17 5 Quantitative Inheritance:
Multigene, Multifactor, Heritability
Ch. 3, 21 -
22 6 Chromosomes and Mapping
Linkage I: Chromosome Theory and the X
Ch. 4 e-prob set Ch 3 due by noon,
Corn lab due in class
24 7 Linkage II: Meiosis and Tetrads Ch. 4, 5 -
29 8 Linkage III: Recombinational Gene Mapping Ch. 5 e-prob set Ch 4 due by noon,
Oct. 1 9 Karyotypes and Chromosomal Aberrations Ch. 14, 13 e-prob set Ch 5 due by noon, (skip 3, 5, 10, and 19-21)  
6 10 Lab: In Silico Genomics I - (get back familiar with ORFs and restriction enzymes)
8 11 Genes as divisible units: Mutation Ch. 7 e-Lab report by noon
13 12 Deconstructing the Genome:  
Molecular techniques review
Ch. 9 -
15 13 Exam I - through session 11. - -
20 14 Genes in Development
Journal Club: How many genes does it take to make an embryo?
20.3; Nusslein-Volhard, Weishaus, Nature 1980 1-2 p brief due at beginning of class
22 15 Journal Club: Details of the Saturation Screen N-V, W, Kluding, Roux Archiv 1984 1-2 p brief due at beginning of class
27 - Fall Break - -
29 16 Regulation of Gene Expression Ch. 18 (17 is review of intro) e-prob set Ch 9 due by noon, skip 16, 24, 25. 
Nov. 3 17 SNPs, Positional Cloning,  Genetic Testing Ch. 11 -
5 18 Developmental Genetics, Stem cells, and Knockouts Ch. 20 -
10 19 Reconstructing the Genome:  
Genome Projects; Genome Organization and Evolution I
Ch. 10 -
12 20 Lab: In Silico Genomics II -
-
17 21 Different Perspectives: Liz Lerman visit (note date change) - e-Lab report due by noon
19 22 Systems Biology  and Proteomics Ch. 12 Gene Chip Animation
Subdividing the eve enhancer/promoter
24 23 Journal Club: Sea Urchin Endo16 Cis-Regulatory System (+ beginning of gene therapy) Yuh, Bolouri, Davidson,  Devel 2001 1-2 p brief due at beginning of class
26 - Thanksgiving Break - -
Dec. 1 24 Proteomics: Yeast Gal Regulatory System, end gene therapy, retroviruses Ch. 12 no brief; problem set instead. Yeast two hybrid, screen, Mass Spec, ELISA, Western
3 25 Genome Organization and Evolution II Ch. 22 problem set due in class.
8 26 Cancer Genetics, open questions, Overview Ch. 19 -
Dec. 12 - Exam 2  2 - 5 pm -

Copyright 2008, Laurel F. Appel, Version F.  http://lappel.web.wesleyan.edu/biol210/biol210syllabus.html
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