An annotated list of good Web resources for Genomics
and other genetics/bioethics/biomedical sites.

Laurel F. Appel, Wesleyan University


Genomics Links.

Human Genome Project Information site http://www.ornl.gov/hgmis/
A site for information about the U.S. and worldwide Human Genome Project.

Their education link, http://www.ornl.gov/hgmis/education/education.html includes:
Educational Materials --including publications, teaching aids, posters, videos, graphics, audio files, and famous geneticists; Special Focus Areas --including students; careers; DOE-funded education research; and HGP-related ethical, legal, and social issues; Finding More Information --basic information on the HGP, its science, and research Includes Human Genome Project Education Resources.
Their roadmap of the next directions to pursue, such as connecting genes to functions and regulation, and proteomics is at http://DOEGenomesToLife.org/ Site sponsored by the U.S. Department of Energy Office of Science, Office of Biological and Environmental Research, Human Genome Program.

A Tour of the Draft Human Genome Sequence http://www.ncbi.nlm.nih.gov/Tour/

A guide for the non-expert to exploring the draft sequence of the human genome. "This website aims to jump-start those who want make use of this information, but are not sure where or how to start." NCBI, the National Center for Biotechnology Information, is a division of the National Library of Medicine (NLM) at the National Institutes of Health (NIH). They also host BLAST sequence queries.

euGenes http://iubio.bio.indiana.edu:8089/
Genomic Information for Eukaryotic Organisms (Fruitfly, Human, Mouse, Weed, Worm, Yeast, Zebrafish)

euGenes provides a common summary of gene and genomic information from databases of the major eukaryotic model organisms, with searches, tools, and help section; automatically updated from the primary databases.

The WWW Virtual Library: Model Organisms http://ceolas.org/VL/mo/

For more on model organisms. There are several "genome projectS" instead of just humans. Comparisons of sequences between species give us a lot more insight than just the data of one sample. The other species being sequenced tend to be the ones we know most about already: the standard model organisms of developmental biology. This site is a catalog of internet resources relating to biological model organisms, and is part of the Biosciences area of the Virtual Library project. It opens with a discussion of why specific model organisms are chosen for specific kinds of research and strengths and weaknesses of different systems, and then links to sites for each organism.

Specifically for Yeast (Saccharomyces cerevisiae):

http://www.proteome.com/databases/YPD/YPDsearch-long.html YPD™ , the Yeast Proteome Database, part of the BioKnowledge™ library, an integrated resource for protein information, Proteome, Inc.
http://genome-www.stanford.edu/Saccharomyces/ The Saccharomyces Genome Database (SGDTM™)
Funded by the National Human Genome Research Institute at the US National Institutes of Health, and hosted by the School of Medicine, Stanford University.

Specifically for Fruitflies (Drosophila melanogaster):

http://flybase.bio.indiana.edu/ Flybase
FlyBase is a comprehensive database for information on the genetics and molecular biology of Drosophila. It includes data from the Drosophila Genome Projects and data curated from the literature. FlyBase is a joint project with the Berkeley and European Drosophila Genome Projects, supported by grants from the U.S. National Institutes of Health and the British Medical Research Council.
http://www.fruitfly.org/ The Berkeley Drosophila Genome Project (BDGP)
The Berkeley Drosophila Genome Project (BDGP) is a consortium of the Drosophila Genome Center (funded by the National Human Genome Research Institute, National Cancer Institute, and the Department of Energy), and the Howard Hughes Medical Institute.
http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aimain/1aahome.htm The Interactive Fly
The Interactive Fly stems from thinking about how the information of developmental biology could be held in an easily retrievable form: what is the most efficacious way to portray a non-linear developmental hierarchy of gene activation and repression, characterized by a high degree of complexity? Currently, Drosophila is the only organism for which one can begin with a list of genes active in the egg and follow the morphological changes and gene interactions through to adulthood. Consequently, Drosophila is a good starting place from which to design an interactive model of development, and cyberspace is the made-to-order medium. (Description by site's author, Dr. Tom Brody.) Available through Flybase.

 

The DNA Learning Center at Cold Spring Harbor Laboratory: http://vector.cshl.org/

"The source for timely information about genes in education." Well-written features, links, experiments, social and historical background. Their "DNA from the Beginning" is a series of modules organized around key concepts. The science behind each concept is explained with animation, images, video interviews, problems, biographies, and links. CSHL is a research and educational institution, with research programs focusing on cancer, neurobiology, plant genetics, genomics and bioinformatics, and a broad educational mission.

General Genetics, Biomedical, and Ethical Issues Links.

OMIM™ Online Mendelian Inheritance in Man. http://www3.ncbi.nlm.nih.gov:80/Omim/

This database is a catalog of human genes and genetic disorders authored and edited by Dr. Victor A.McKusick and his colleagues at Johns Hopkins and elsewhere, and developed for the World Wide Web by NCBI, the National Center for Biotechnology Information. The database contains textual information, pictures, and reference information. It also contains links to NCBI's Entrez database of MEDLINE articles and sequence information.

Genetics, Medical Genetics, Bioethics Links http://www.mmc.edu/edu/medgen/Links.html

Good for background information on Biochemistry, Cell Biology & Developmental Biology; listing of sites for Medical Genetics, Ethics. Good selection of useful sites, kept up to date, from Meharry Medical College, Nashville TN.

NOAH: New York Online Access to Health http://www.noah-health.org/index.html

Great site for general medical information. Good, easy to understand information available in both English and Spanish. Hosted by New York Public Libraries and others.

Medline/PubMed: http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?db=PubMed

Search PubMed, a service of the National Library of Medicine (NIH). Provides access to over 11 million citations from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Pub Med also now allows you to search on-line versions of some of the best classic textbooks:(Molecular Biology of the Cell, Developomental Biology, Intro. to Genetic Analysis, Cancer Medicine, Genes and Disease, etc.) at http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?db=Books They also now have a health information site, http://medlineplus.gov/

Council for Responsible Genetics http://www.gene-watch.org/

The Council for Responsible Genetics is a non-profit/non-governmental organization devoted to fostering public debate about the social, ethical, and environmental implications of the new genetic technologies.

Bioethics.net -- The American Journal of Bioethics Online http://ajobonline.com/

(Includes material previously on the University of Pennsylvania Center for Bioethics site.)
Sections both for professionals and for laypeople, including Bioethics for Beginners, Cloning & Genetics, Who Owns Life, a virtual library, and updates on issues in the news.
On-line Textbook and Textbook - style resources.

The Merck Manual of Medical Information. http://www.merck.com/pubs/mmanual_home/contents.htm

A fairly readable home medical guide.

Kimball's Biology Pages http://biology-pages.info

Good definitions of basic terms and concepts of genetics, biochemistry and molecular biology.
There are many other textbooks out there with on-line versions, but this one is gets to the the point quickly, and doesn't waste time with fancy graphics that take forever to load.


Other Useful Links:

PIMMS K-12 Math and Science Links

Wesleyan University Homepage

Dr. Appel's Homepage

My own K-12 & other Public Science Links

For further information or to suggest other sites,e-mail lappel@wesleyan.edu
Copyright 2001, Laurel F. Appel. Last updated, 5 September 2002, LFA.